Research Article

Estimating Network Kinetics of the MAPK/ERK Pathway Using Biochemical Data

Figure 2

Examples of the probability distribution (a, b, and c) and trace plots (d, e, and f) of reaction rates 2 (which indicates the simultaneous recruitment of Shc and Grb2-SOS complex from the cytosol to the cell membrane by the recruitment of EGFR (a and d)), 16 (which shows the activation of MEK proteins by active Raf (b and e)), and 38 (which refers to the dissociation of active ERK and RSK complex (c and f)) of Model 2 under after 85,000 burn-in runs.
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(c)
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(d)
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(e)
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(f)