Estimating Network Kinetics of the MAPK/ERK Pathway Using Biochemical Data

Figure 3

Simple representation of the MAPK/ERK pathway via Model 2 under Δ𝑡=5. The thickness of the arrow indicates the speed of the interaction. The thick arrows represent fast interactions (estimated reaction rates have power 10⁻¹), only simple arrows describe moderately slow reactions (estimated reaction rates have power 10⁻² or 10⁻³), and finally dotted lines show very slow reactions among substrates (estimated reaction rates have power 10⁻⁴ or 10⁻⁵).