Malaria Research and Treatment / 2010 / Article / Tab 1 / Review Article
The Survival Strategies of Malaria Parasite in the Red Blood Cell and Host Cell Polymorphisms Table 1 Geographic variations in malaria pathogenesis.
South East Asia Africa Ref Low transmission in general High transmission [38 ] Severe malaria affects all age group Severe malaria affects mostly the children under 5 yrs of age [39 ] Multiorgan failure is common with seizures, respiratory distress, and anemia being more common in children whereas renal and hepatic failures are in adults. Cerebral malaria, severe anemia, and respiratory distress are common [39 , 40 ] Total parasite burden is associated with risk of severe malaria and deaths This relationship is less clear as children tolerate high parasitemias without developing severe malaria. [38 ] Rosetting is not associated with severe malaria Rosetting is associated with severe malaria [41 ] Platelet-mediated clumping is associated with severe malaria Platelet-mediated clumping is associated with severe malaria or high parasitemia [41 ]