Characterization of the Duffy-Binding-Like Domain of Plasmodium falciparum Blood-Stage Antigen 332
Figure 3
IgG reactivity to Pf332-DBL and PfEMP1-DBL1α in children and asymptomatic adults. Antibodies specific for Pf332-DBL and PfEMP1-DBL1α in plasma samples collected from asymptomatic adults in Uganda, Burkina Faso, and Mali as well as from children with mild or severe malaria in Uganda. Plasma samples were analyzed in ELISA at a dilution of 1 : 500. IgG reactivity is expressed as OD ratio and calculated as follows: (OD sample − OD background)/(OD Swedish nonimmune donor pool − OD background). (a) Adults in Kampala, Uganda; (b) children with mild or severe malaria in Apac, Uganda; (c) adults in Burkina Faso and (d) adults in Mali. Box plots show medians with 25th and 75th percentiles and whiskers for 10th and 90th percentiles. and indicate significant differences between groups (P < 0.01 and P < 0.001, resp.).
