Malaria Research and Treatment / 2011 / Article / Tab 1 / Review Article
Malaria Treatment Policy Change and Implementation: The Case of Uganda Table 1 Antimalarial drug efficacy studies in Uganda from 2000 to 2001: results for children less than 5 years.
Period of study Site, transmission intensity Researchers/authors and/or publication Protocol used Drug or drug combination Treatment failure rates (%) Parasitological failure rate (%) After 14 days After 28 days 2000 Kampala, Medium [14 ] WHO 1996 SP 10 — — AQ 7 — — AQ/SP 3 — — July 2000 to August 2001 Kampala, Medium [15 ] Longitudinal study SP 17 — 32 AQ/SP 1 — 2 AS/SP 1 — 5 July to Sept 2001 Kaberamaido, high [16 ] WHO 1996 CQ — 45 — SP — 16 — CQ/SP — 12 — October 2001 Kabale, low [17 ]* WHO 1996b CQ 7.5 — — SP 0 — — CQ/SP 0 — — March 2001 to Jan 2002 Kampala, Medium [18 ]* WHO 1996 SP — 15 30 CQ/SP — 7 17 AQ/SP — 0 1 Dec 2001 to March 2002 Tororo, high [7 ] WHO 1996 CQ/SP 8 — 40 AQ/SP 0 — 15 SP 9 — 42 Jan to Nov 2002 Bundibugyo, high [19 ] WHO 2002 SP 23.4 37 — AQ 8.8 20.6 — CQ/SP 6.0 22.8 — Aug 2002 to July 2003 Mulago Hospital, Kampala Medium [9 ] WHO 1996 CQ/SP — 35 — AQ/SP — 9 — AQ/AS — 2 — Dec 2002 to June 2003 Kanungu, low [8 ] WHO 1996 CQ/SP — 67 73 AQ/SP — 35 38 Kyenjojo, high [8 ] WHO 1996 CQ/SP — 37 58 AQ/SP — 14 24 Mubende, medium [8 ] WHO 1996 CQ/SP — 34 43 AQ/SP — 13 14 All sites combined [8 ] WHO 1996 CQ/SP 22 Range 34–67 Range 43–73 AQ/SP 8 Range 13–35 Range 14–38 Nov 2002 to May 2004 Jinja, low to medium [20 ] WHO 2003 CQ/SP — 40 — AQ/SP — 13 — AQ/AS — 4 — Arua, medium to high [20 ] WHO 2003 CQ/SP — 46 — AQ/SP — 14 — AQ/AS — 9 — Tororo, high [20 ] WHO 2003 CQ/SP — 34 — AQ/SP — 18 — AQ/AS — 12 — Apac, high [20 ] WHO 2003 CQ/SP — 22 — AQ/SP — 7 — AQ/AS — 10 — All sites combined [20 ] WHO 2003 CQ/SP — 22–46 — AQ/SP — 7–18 — AQ/AS — 4–10
*Study participants included both children and adults; results reported for both children and adults together. AS: Artesunate; AQ: Amodiaquine, CQ: Chloroquine, SP: Sulfadoxine-Pyrimethamine.
