Subacute Therapeutic Dosing of Artemether-Lumefantrine and Artesunate-Amodiaquine Combination Preserves Plasma Cholesterol, Renal Antioxidant Status, and Organ Weights in Rats

Table 2

Effects of artemether-lumefantrine and artesunate-amodiaquine combination on organ systems relative to their body weights in rats.

Treaments	LW^a	KDW^a	LGW^a	HTW^a	BRW^a
Control	26.94±2.78	6.10±0.64	7.99±1.61	3.89±0.45	3.45±0.51
A+L	25.41±1.75	5.36±0.29	9.39±1.95	3.53±0.52	4.47±0.09
(1.14/6.86 mg/kg/d)	(6.68)^a	(12.1)^a	(−17.5)^a	(9.3)^a	(−26.2)^a
A+A	24.30±0.66	4.70±0.64	7.02±1.06	2.83±0.15^∗	5.64±0.56
(2.86/8.58 mg/kg/d)	(9.8)^a	(23.0)^a	(12.1)^a	(27.2)^a	(−63.5)^a

Results expressed as mean ±SEM. Values in parenthesis represent % change; (−): increase; (+): decrease, (a) % change relative to control group. ^∗𝑃<0.05 when compared with control. ^aExpressed units as g/kg body weight. A+L: artemether + lumefantrine; A+A: artesunate + amodiaquine; LW: liver weight; KDW: kidney weight; LGW: lung weight; HTW: heart weight; BRW; brain weight.