Artesunate Exerts a Direct Effect on Endothelial Cell Activation and NF-B Translocation in a Mechanism Independent of Plasmodium Killing
Figure 2
(a) TNF-α mRNA expression in the brains of uninfected (open bars), infected (closed bars), or infected mice that received a single dose of artesunate (200 mg/Kg) on the fifth day of infection. (b) Inhibition of TNF-α production during murine endotoxic shock after treatment with artesunate. The results are expressed as the mean ± SEM from three animals per group of three experiments. Statistically significant differences () between the control and P. berghei-infected groups are indicated by +, and significant differences () between the untreated and artesunate-treated infected mouse groups are indicated by *.
