Increased Prevalence of Mutant Allele Pfdhps 437G and Pfdhfr Triple Mutation in Plasmodium falciparum Isolates from a Rural Area of Gabon, Three Years after the Change of Malaria Treatment Policy

Table 1

Prevalence of mutations conferring resistance to sulfadoxine/pyrimethamine in Plasmodium falciparum isolates from Gabon.

Gene	Genotypes	2005		2008
			%		%
Pfdhfr	108N	29/29	100	60/62	96.7	NS
	59R	27/29	93.1	61/62	98.4	NS
	51I	14/29	48.3	59/62	95.2	<0.01
	Double mutation: 51I-59R	21/29	72.4	62/62	100	<0.01
	Double mutation: 51I-108N	21/29	72.4	60/62	97.7	<0.01
	Double mutation: 59R-108N	29/29	100	60/62	96.7	<0.01
	Triple mutation: 51I-59R-108N	21/29	72.4	57/62	91.9	0.03
Pfdhps	437G	11/29	37.9	42/62	67.7	<0.01