Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis
Table 3
Comparing MRI status, corticosteroid therapy, and RNFL* values in nonaffected eyes.
RNFL Non-ON Eyes*
Year 1
P value
Year 2
P value
MRI+§ ()
MRI−|| ()
MRI+ ()
MRI− ()
Overall (SD)¶
103.9 (10.5)
102.2 (9.4)
.56
104.1 (12.2)
104.3 (9.9)
.94
Superior
131.1 (15.6)
132.9 (13.0)
.67
134.4 (20.6)
135.3 (13.6)
.87
Inferior
134.0 (16.9)
125.4 (12.7)
.07
131.0 (17.9)
127 (14.9)
.42
Nasal
84.3 (17.0)
80.4 (17.7)
.46
84.0 (18.0)
84.7 (21.4)
.89
Temporal
66.3 (13.0)
70.0 (10.1)
.30
66.9 (13.6)
70.7 (13.8)
.34
Steroid# ()
Untreated** ()
Steroid ()
Untreated ()
Overall (SD)
103.6 (9.3)
103.0 (11.0)
.84
104.7 (10.5)
103.6 (12.5)
.75
Superior
130.7 (12.4)
132.8 (16.7)
.63
136.0 (14.7)
133.5 (21.4)
.63
Inferior
131.4 (14.2)
130.5 (17.8)
.85
130.2 (17.8)
129.0 (16.2)
.80
Nasal
85.8 (18.6)
80.0 (15.5)
.23
82.8 (19.8)
85.7 (18.6)
.60
Temporal
66.6 (11.2)
68.6 (13.0)
.56
69.7 (13.8)
66.8 (13.7)
.47
*Retinal nerve fiber layer thickness (μm); §Abnormal baseline magnetic resonance imaging study [8]; || Normal baseline magnetic resonance imaging study; ¶Mean overall RNFL value (standard deviation), and mean RNFL values in the superior, inferior, nasal and temporal quadrants; # Patients treated with the equivalent of 1000 mg of intravenous methyl-prednisolone for acute management of optic neuritis; **Patients not treated acutely for optic neuritis.