Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis
Table 1
Summary of studies assessing the utility of neurofilaments as biomarkers of axonal damage in patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS).
Biomarker
Fluid
Study design
Observations
Associations with clinical measures
Ref.
NF-L
CSF
RRMS (); LP on trial initiation and 2 yr
78% patients showed ↑ at 0 or 2 yrs. Associated with recent relapse. No relation with age, gender, or disease duration.