Multiple Sclerosis International

Research Article

Epitope Analysis of Cerebrospinal Fluid IgG in Japanese Multiple Sclerosis Patients Using Phage Display Method

Table 1

Common peptide motifs in MS patients.
MS1MS2MS3MS4MS5MS6.1MS6.2MS6.3MS7MS8MS9MS10MS11MS12MS13MS14MS15
[PHSRPPTK][IRLPH][MIKA][QPEY][HHPAHG][DPYQ][DPYQLAWE][DPYQxP][PAATARQH][NPIEKYL][KRTRINK][FFSxSP][WHDA][WNEPDWLK][HNAL]
PHMRPDTKIRLPHMNKTQPEYHHPAHGDPYQDYYQQHWEDPYQVPPATTAYEHNPASKYLHRTRNNKFYSMDPWHDMWYQPDWIQHNAL
PHLRPATKIQLPHMIKHQPQYHHPAHGDPYQDPYQLPFDEFYQYPPAPTASDHNPVLWYLKRTRKSKFFSNNPWHDAWPEPDWLKENAL
EHMRPALKISLPHMSKAQPMYHHPAHQDPYQAYYQVPWEDPYQLPPAPTAEQSNPASAYLKRIMINKFFRRDPWHELWSNPDWLFHIAL
YHSRPPMKIALPHHHPAHNDQYQDPYQTAFFGPYQDPPAITASESNPIDTHLFYTMDPWHSVWNHKDILK
PHMKPFQKIRFPHHHPAHMDPWXIAWTAFYQQPPAATARQTNPSETYVFFRESP
KHARPMLKVRLPHGAYQLAWAIPMQKPPALTAVQMNPIETLLFFTNNP
PHRPPMTKVSFPHLNYQHPPYATNRFHNPSGYYLFFSPSP
PHSRPLPKITLPXNPINSYLFFSPSP
LHXRPPTKYRLPH[SPPXMH]NPLEHFFFFSSSP
PHRTPQAKVTLPDNPVDMHMFFRPSP
KHLPAPTKQQLPHSPPKMHNPILHWLFFRSSP
YHSRGFPLSPRNMHNPITQLLFFTDSP
[NPVEF]SPVHMHNPIYRYIFFRSSP
SPPLMHNPAYYLLFYWPDP
NPIEWSPKSMHNPLLKHLFFSHEP
NPVEFFSPRMHNPLEPMLFYSLSP
NPVENNLGTMWLFFHVSP
GPTHKDVFLSNTP
GPIHKDRFLSSNP
FMSRTP
YFSTTP
Parentheses indicate common peptide motifs in an MS patient.
Peptide sequences derived from random peptide library are listed below.
MS6.1, 6.2, 6.3 indicate 3 different samples from MS patient 6.