Reduced ErbB4 Expression in Immune Cells of Patients with Relapsing Remitting Multiple Sclerosis
Figure 1
ErbB4 expression in unstimulated PBMCs of patients with RR-MS and aged matched healthy controls as was measured by flow cytometry. The mean fluorescence intensity (MFI) of ErbB4 in PBMCs of patients with RR-MS was significantly lower than that in PBMCs of healthy controls (a). The MFI of ErbB4 on unstimulated T cells, monocytes, and B cells of patients with RR-MS was significantly reduced as compared with healthy controls (b). After immunoprecipitation with monoclonal ErbB4 antibody, the cell lysates were processed by Western blot analysis and probed by polyclonal antibody. Large cell carcinoma H661 cell line was used as positive control (PC). H1299 human lung adenocarcinoma cell line was used as negative control (NC). The donors here are different from those that are described in figure a and b: H1-2 are healthy controls, and P1-5 are for RR-MS patients (c).
