Clinical Study

Overall Memory Impairment Identification with Mathematical Modeling of the CVLT-II Learning Curve in Multiple Sclerosis

Table 2

Values of the Model’s coefficients for the averaged learning curves.

NoGroupModel’s coefficients ± asymptotic standard error 𝑅 2
𝐵 2 𝐵 3 𝐵 4

(1)All healthy participants 0 . 6 5 ± 0 . 0 6 7 . 2 8 ± 0 . 1 3 1 4 . 1 7 ± 0 . 2 2 0.9987
(2)Female healthy participants 0 . 7 0 ± 0 . 0 7 7 . 6 3 ± 0 . 1 5 1 4 . 3 8 ± 0 . 2 3 0.9982
Significance level, P 0.0750.00160.20
(3)Male healthy participants 0 . 4 7 ± 0 . 0 6 5 . 9 0 ± 0 . 1 7 1 3 . 5 8 ± 0 . 4 8 0.9978
(4)All MS patients 0 . 7 0 ± 0 . 0 4 6 . 1 6 ± 0 . 0 9 1 2 . 0 1 ± 0 . 1 3 0.9992
(5)Female MS patients 0 . 7 2 ± 0 . 0 4 6 . 3 5 ± 0 . 0 9 1 2 . 4 4 ± 0 . 1 3 0.9993
Significance level, P 0.320.0060.002
(6)Male MS patients 0 . 6 4 ± 0 . 0 6 5 . 6 6 ± 0 . 1 0 1 0 . 8 6 ± 0 . 1 7 0.9987
(7)Male healthy participants, cluster referring to lower memory functioning using 𝐵 3 with low values0.4407± 0.0902 3 . 9 1 ± 0 . 3 0 1 3 . 7 2 ± 0 . 9 5 0.9956
Significance level, P 0.680.0020.85
(8)Male healthy participants, cluster referring to higher memory functioning using 𝐵 3 with high values 0 . 5 2 7 4 ± 0 . 1 7 7 7 . 5 ± 0 . 3 6 1 3 . 4 6 ± 0 . 8 5 0.9850
(9)Male healthy participants, cluster referring to lower memory functioning using 𝐵 4 with low values 1 . 1 3 5 3 ± 0 . 3 0 4 4 4 . 3 8 ± 0 . 4 2 9 . 9 6 ± 0 . 3 7 0.9838
Significance level, P 0.060.010.0007
(10)Male healthy participants, cluster referring to higher memory functioning using 𝐵 4 with high values 0 . 3 3 6 1 ± 0 . 0 3 1 7 6 . 3 9 ± 0 . 0 9 1 5 . 7 6 ± 0 . 4 9 0.9994
(11)Male MS patients, cluster referring to lower memory functioning using 𝐵 3 with low values 0 . 6 5 0 5 ± 0 . 0 3 4 4 4 . 2 6 ± 0 . 0 6 9 . 8 1 ± 0 . 1 1 0.9995
Significance level, P 0.730.000060.002
(12)Male MS patients, cluster referring to higher memory functioning using 𝐵 3 with high values 0 . 6 1 7 9 ± 0 . 0 8 2 1 6 . 9 7 ± 0 . 1 4 1 1 . 8 5 ± 0 . 2 5 0.9971
(13)Male MS patients, cluster referring to lower memory functioning using 𝐵 4 with low values 0 . 8 1 9 2 ± 0 . 0 2 5 2 5 . 1 7 ± 0 . 0 3 8 . 7 4 ± 0 . 0 3 0.9998
Significance level, P 0.0440.0130.0014
(14)Male MS patients, cluster referring to higher memory functioning using 𝐵 4 with high values 0 . 5 0 8 7 ± 0 . 1 0 4 1 6 . 3 7 ± 0 . 2 8 1 4 . 2 1 ± 0 . 6 9 0.9946
(15)Female healthy participants, cluster referring to lower memory functioning using 𝐵 3 with low values 0 . 7 2 3 1 ± 0 . 0 8 0 7 5 . 2 7 ± 0 . 2 4 1 4 . 2 8 ± 0 . 3 4 0.9976
Significance level, P 0.750.000250.72
(16)Female healthy participants, cluster referring to higher memory functioning using 𝐵 3 with high values 0 . 6 8 7 7 ± 0 . 0 6 4 8 . 5 6 ± 0 . 1 2 1 4 . 4 3 ± 0 . 1 9 0.9984
(17)Female healthy participants, cluster referring to lower memory functioning using 𝐵 4 with low values 2 . 0 7 6 7 ± 3 . 6 1 9 0 6 . 9 8 ± 1 . 4 4 1 0 . 8 1 ± 0 . 9 2 0.7277
Significance level, P 0.720.660.017
(18)Female healthy participants, cluster referring to higher memory functioning using 𝐵 4 with high values 0 . 6 6 1 6 ± 0 . 0 8 5 5 7 . 6 7 ± 0 . 2 0 1 4 . 6 3 ± 0 . 3 3 0.9971
(19)MS female patients, cluster referring to lower memory functioning using 𝐵 3 with low values 0 . 6 2 8 6 ± 0 . 0 6 1 4 5 . 0 6 ± 0 . 1 4 1 1 . 6 2 ± 0 . 2 4 0.9984
Significance level, P 0.0240.000030.0011
(20)MS female patients, cluster referring to higher memory functioning using 𝐵 3 with high values 0 . 8 5 0 7 ± 0 . 0 1 0 9 8 . 0 8 ± 0 . 0 2 1 3 . 6 3 ± 0 . 0 2 0.9999
(21)MS female patients, cluster referring to lower memory functioning using 𝐵 4 with low values 0 . 8 6 4 2 ± 0 . 0 8 1 2 5 . 4 0 ± 0 . 1 1 9 . 8 8 ± 0 . 1 3 0.9981
Significance level, P 0.0840.00050.00003
(22)MS female patients, cluster referring to higher memory functioning using 𝐵 4 with high values 0 . 6 5 4 1 ± 0 . 0 4 3 1 7 . 0 1 ± 0 . 1 1 1 4 . 2 6 ± 0 . 1 7 0.9992