Research Article
Cortical Pathology in RRMS: Taking a Cue from Four Sisters
Table 1
Demographic, clinical, and MRI characteristics of four sisters affected with multiple sclerosis.
| | | Sister 1 | Sister 2 | Sister 3 | Sister 4 |
| | Age (years) | 49 | 48 | 46 | 43 | | Disease duration (years) | 5 | 6 | 3 | 2 | | Type of onset | Brainstem | Brainstem | Optical nerve | Spinal cord | | VEP | + | + | + | n.d | | BOIgG | + | + | + | + | | EDSS | 3.0 | 2.0 | 1.0 | 3.0 | | Treatment | IFN beta 1b (since 2008) | Natalizumab (since 2012) | IFN beta 1a (since 2010) | Natalizumab (since 2012) | | Relapses in the last 2 years | 2 | 2 | 1 | 3 | | WM brain lesions | 6 | 15 | 10 | 16 | | SCL | 0 | 0 | 0 | 1 | | CEL | 0 | 0 | 0 | 0 | | CLs | 11 | 14 | 18 | 13 | | CL volume (mm3) | 1225 | 1540 | 2100 | 1420 | | Global CTh (mm) | 2.31 ± 0.5 (1.8–3.2) | 2.37 ± 0.6 (1.8–3.1) | 2.24 ± 0.5 (1.6–3.0) | 2.30 ± 0.7 (1.9–3.3) |
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VEP: visual evocated potentials; BOIgG: oligoclonal bands; EDSS: expanded disability status scale; WM: white matter; SCL: spinal cord lesions; CEL: contrast enhancing lesion; CL: cortical lesion; CTh: cortical thickness.
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