Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years: A Longitudinal Study

Table 3

Relationship between cortical volume at baseline and changes with lesion burden over the followup in patients with relapsing-remitting multiple sclerosis.

CV	Coefficient	Standard error	𝑇	𝑃 value
Baseline
Age at baseline	−2373.48	438.79	−5.41	<0.0001
Disease duration	−608.11	680.62	−0.89	0.37
T2-LV	−1.39	0.28	−4.93	<0.0001
Baseline to year 1
Age at baseline	−0.005	0.06	0.09	0.93
Disease duration	−0.04	0.08	−0.48	0.63
% Change T2-LV	0.005	0.009	0.52	0.61
Year 1 to year 2
Age at baseline	0.04	0.05	0.70	0.48
Disease duration	0.08	0.08	1.02	0.31
% Change T2-LV	0.01	0.007	1.51	0.13
Baseline to year 2
Age at baseline	0.03	0.03	0.90	0.37
Disease duration	0.008	0.05	0.15	0.88
% Change T2-LV	0.002	0.004	0.74	0.46

LV: lesion volume; CV: cortical volume.
The statistical analysis between T2-LV and CV was performed using regression (baseline) and mixed effect model (year 1 and year 2) analyses on all bi-monthly serial MRI time points of the study.
The LVs are in milliliters.