Diffusion Tensor Imaging in NAWM and NADGM in MS and CIS: Association with Candidate Biomarkers in Sera

Figure 2

ADC and FA values in different brain regions of multiple sclerosis (MS) subtypes, clinically isolated syndrome (CIS), and healthy controls (HC). The length of the box represents the interquartile range, which includes the middle 50% of the values. The line through the middle of each box represents the median. The error bars show the minimum and maximum values (range). RRMS, relapsing remitting MS; SPMS, secondary progressive MS; PPMS, primary progressive MS; ADC, apparent diffusion coefficient; FA, fractional anisotropy. Reported 𝑃 values were calculated using the univariate analysis of variance with age as covariate followed by post hoc multiple pairwise comparisons with Bonferroni correction. ^∗∗𝑃<0.0006 (𝑛 = 80), ^∗𝑃<0.005 (𝑛=10) when compared to HC. ^##𝑃<0.0006 (𝑛=80), ^#𝑃<0.005 (𝑛=10) when compared to CIS. ^¤𝑃<0.005  (𝑛=80) in comparison to RRMS. ^∅𝑃<0.005 (𝑛=80) in comparison to PPMS.

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