Diffusion Tensor Imaging in NAWM and NADGM in MS and CIS: Association with Candidate Biomarkers in Sera

Table 2

Clinicoradiological correlations between DTI indices and clinical findings in RRMS patients (𝑛=35).

	EDSS	Relapses^a	Age	DD
Internal capsule
ADC	−0.094	−0.149	−0.078	−0.072
FA	0.310	−0.128	−0.143	0.200
Corona radiata, posterior
ADC	0.099	0.002	0.083	0.080
FA	0.349	−0.032	0.151	0.381
Corona radiata, anterior
ADC	0.200	−0.177	0.036	0.055
FA	0.359	−0.071	−0.062	0.307
Centrum semiovale
ADC	0.027	−0.021	0.155	0.149
FA	0.122	0.096	−0.057	0.162
Corpus callosum, genu
ADC	0.061	−0.277	0.133	−0.002
FA	−0.224	0.153	−0.221	0.002
Corpus callosum, splenium
ADC	0.028	0.277	−0.368	0.051
FA	−0.115	−0.017	0.175	0.073
Thalamus
ADC	−0.339	−0.110	−0.323	−0.332
FA	0.479**	−0.304	0.384	0.292
Caudate nucleus
ADC	−0.182	−0.146	−0.132	−0.427**
FA	0.390	0.058	0.264	0.139

EDSS: expanded disability status scale; DD: disease duration; ADC: apparent diffusion coefficient; FA: fractional anisotropy.
Significant 𝑃 values: ^∗∗𝑃<0.001.
aNumber of relapses in the two years before study entry.