Fatigue and Sleep-Disordered Breathing in Multiple Sclerosis: A Clinically Relevant Association?

Table 1

Demographic and clinical characteristics in severely fatigued MS patients with and without sleep-disordered breathing.

	No SDB (AHI < 5/h)	SDB (AHI ≥ 5/h)	P
n (%)	41 (59%)	28 (41%)
Female sex, n (%)	32 (78%)	16 (57%)	0.06
Age (y)	47.4 ± 8.3	53.3 ± 9.5	0.01
BMI	25.4 ± 5.2	26.8 ± 4.2	0.27
Disease duration (y)	13.8 ± 8.9	13.6 ± 8.8	0.92
Disease subtype			0.73
RRMS	3	6
SPMS	25	35
EDSS	5.9 ± 1.5	5.8 ± 1.3	0.79
FSS	5.7 ± 0.7	5.5 ± 0.9	0.36
ESS	9.4 ± 4.7	9.7 ± 3.8	0.79
EDS (ESS ≥ 10)	18 (44%)	17 (61%)	0.13

BMI: body mass index (kg/m²), EDS: excessive daytime sleepiness, EDSS: Expanded Disability Status Scale, ESS: Epworth Sleepiness Scale, FSS: Fatigue Severity Scale, RRMS: relapsing-remitting multiple sclerosis, SPMS: secondary progressive multiple sclerosis.