Table 2: Gender-related differences in MS patients with severe fatigue.

FemaleMaleP

n (%)48 (70%)21 (30%)
Age (y)49 ± 9.351 ± 9.20.73
Disease duration (y)14.4 ± 9.111.9 ± 7.70.16
Disease subtype0.71
 RRMS72
 SPMS4119
EDSS5.9 ± 1.45.8 ± 1.40.78
ESS9.7 ± 4.59.2 ± 3.80.65
EDS (ESS ≥ 10)25 (52%)10 (48%)0.49
BMI26.3 ± 5.225.3 ± 3.80.12
No SDB (AHI < 5/h)32 (67%)9 (43%)0.06
AHI5.2 ± 9.918.5 ± 24.7<0.001
ODI7.1 ± 7.918.1 ± 22.4<0.001
SaO2 min (%)78.9 ± 14.675.5 ± 19.10.58

AHI: apnea-hypopnea index, BMI: body mass index, EDS: excessive daytime sleepiness, EDSS: Extended Disability Status Scale, ESS: Epworth Sleepiness Scale, ODI: oxygen-desaturation index, RRMS: relapsing-remitting multiple sclerosis, SaO2 min: minimal O2 saturation, SDB: sleep-disordered breathing, SPMS: secondary progressive multiple sclerosis.