++ Higher CSF levels, progressive MS forms/worst disability scores +++ Disability progression in NMO
See also A,C
S100B
+ Disability progression in NMO
See also A,C
BDNF
++ Lower CSF levels in SPMS patients
See also C, D, F
Unblocked α4 integrin
+ Prognostic factor of risk for PML
See also C, F
(3) Imaging
RNFL thinning
+ Correlation with brain atrophy measures and disease progression
See also D, F
Hyperintense T2-weighted lesions
+/−
See also A, C, D
Black holes
+/−
See also D
Whole brain atrophy measures
++ Worsening rates at MS onset, prognostic biomarker of disability after 8 years
Gray matter atrophy measures
+++ Higher worsening rates, progressive forms/early CIS conversion to RRMS
UCCA atrophy
++ Progressive forms, good correlation with EDSS, bad prognostic in RRMS
See also B
DTI abnormalities
+++ Early prognostic biomarker of relapse
See also C, D
Corpus callosum DTI abnormalities
+++ Bad prognostic biomarker
See also A
Spinal cord DTI abnormalities
+++ Good correlation with EDSS scores
Early MRS abnormalities
++ Bad prognostic biomarker
See also A, C, D
Combined EPs
+++ Good prognostic biomarker, especially for benign disease forms
See also A, C, D
SSR
++ Correlation with higher EDSS scores
See also A
(F) Biomarkers of therapeutical response (criteria i, iv, v, vi, and vii)
(1) Genetic-immunogenetic
HLA-DRB1*0401, 0408, 1601
+++ Higher risk for developing neutralizing antibodies against IFN-B
See also A
(2) Laboratorial
MRZ reaction
++ B-cell immunity targeted therapy
See also A, E
Anti-MOG
++ B-cell immunity targeted therapy
See also A, B, E
Fetuin-A
+++ Decreased CSF levels in Natalizumab responders
See also C
MBP
+++ Decrease in CSF levels in methylprednizolone responders
See also C
CSF lipocalin 2
++ Decreased CSF levels in Natalizumab responders
See also A
Unblocked α4 integrin
+++ Therapeutical response to Natalizumab
See also C, E
NF-L
+++ Normalized CSF levels in Natalizumab responders
See also A, C
BDNF
+++ CSF elevation in Glatiramer Acetate responders
See also C, D, E
TRAIL
++ Serum levels good predictors of response in IFN-B
MxA
++ Serum levels good predictors of response in IFN-B
sVCAM
++ CSF alterations in IFN-B responders
See also C
Th17 immune profil
+/− Immune response exacerbation by IFN-B
Vitamin D
+++ Increased levels in IFN-B responders
See also A, C
sICAM-1
+ Lower levels in Cladribine responders
See also C
sE-Selectin
+ Lower levels in Cladribine responders
(3) Imaging
RNFL
+++ Biomarker of therapeutical efficacy for several agents
See also D, E
Classification of biomarkers. +++ very strong correlation, ++ strong correlation, + modest correlation, and +/− controversial correlation. Criteria used for classification., (i) Biological rationale; (ii) clinical rationale; (iii) predictability of disease initiation, reactivation or progression, or of disease differentiation; (iv) sensitivity and specificity; (v) reproducibility; (vi) practicality; (vii) correlation with therapeutical outcome; (viii) correlation with prognosis and disability. Biomarkers of more than one category are indicated in the third column.