Lower gray matter MTR-peak height at baseline is an independent predictor of accumulation of disability over 8 years as measured by the Expanded Disability Status Scale (EDSS).
Lower MTR in the right primary motor cortex correlated with disability as measured by EDSS. Lower MTR in the right parietal and occipital cortices correlated with poorer performance on PASAT.
Reduced gray matter peak height MTR is the best independent predictor of disability as measured by EDSS, and only independent predictor of cognitive impairment as measured by the Multiple Sclerosis Functional Composite (MSFC).