Olfactory Dysfunction in Patients with Neuromyelitis Optica

Figure 1

Binding of serum NMO-IgG to the olfactory bulb as demonstrated by indirect immunohistochemistry on formalin-fixed rat tissue cryosections. Binding of the patient’s IgG is shown in green (AF488). See method section for details. The figure shows a transverse section through the right olfactory bulb near the medial surface. Arrowheads = pia mater; arrows = microvasculature; GL = olfactory glomeruli; ON = peripheral olfactory nerves (ON); NL = nerve fibre layer; CT = connective tissue next to the medial surface of the olfactory bulb.