Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis
Table 1
Demographics.
All MS
RRMS
SPMS
PPMS
Healthy controls
No. of participants
101
64
24
13
16
Age, year, mean ± SD
44 ± 12
39 ± 11
55 ± 8
56 ± 7
40 ± 9
Women, (%)
75 (74%)
41 (64%)
17 (71%)
6 (46%)
11 (69%)
Disease duration, years, mean ± SD
11.5 ± 10.2
7.1 ± 6.3
22.6 ± 9.6
12.5 ± 11.2
Median EDSS (range)
3 (0–8)
2 (0–6.5)
6 (2.5–8)
6 (2.5–8)
25FTW, sec, median (interquartile range)
4.7 (4.2–35.0)
4.5 (3.9–12.4)
6.5 (5.9–16.5)
7.6 (5.4–35.0)
9-HPT, sec, median (interquartile range)
24 (20–28)
21 (19–25)
28 (23–35)
32 (26–39)
PASAT-3, median score (interquartile range)
51 (38–60)
51 (40–60)
49 (39–60)
50 (32–60)
RRMS: relapsing-remitting multiple sclerosis, SPMS: secondary progressive multiple sclerosis, PPMS: primary progressive multiple sclerosis, EDSS: expanded disability status scale, 25FTW: Timed 25-Foot Walk, 9-HPT: 9-Hole Peg Test, PASAT-3: Paced Auditory Serial Addition Task-3, second version. Disease duration is measured in years since the first reported symptoms attributable to MS.
