Quantitative MRI Demonstrates Abnormality of the Fornix and Cingulum in Multiple Sclerosis
Table 2
(a) Fornix correlations with disability and MSFC. (b) Cingulum correlations with disability and MSFC.
(a)
Outcome variable
FA
MD
Parallel diff.
Perp. diff.
MTR
Disease duration
−0.22 (0.03)
0.26 (0.008)
0.25 (0.01)
0.26 (0.01)
−0.17 (0.10)
EDSS
−0.30 (0.003)
0.29 (0.003)
0.26 (0.01)
0.3 (0.003)
−0.18 (0.07)
-score 25FTW
0.20 (0.06)
−0.17 (0.11)
−0.13 (0.25)
−0.20 (0.06)
0.008 (0.94)
-score 9-HPT
0.33 (0.002)
−0.35 (0.001)
−0.30 (0.005)
−0.34 (0.001)
0.21 (0.05)
-score PASAT-3
0.24 (0.03)
−0.23 (0.04)
−0.13 (0.24)
−0.26 (0.02)
0.24 (0.03)
(b)
Outcome variable
FA
MD
Parallel diff.
Perp. diff.
MTR
Average cingula
Disease duration
−0.22 (0.03)
0.11 (0.28)
−0.14 (0.18)
0.19 (0.05)
−0.05 (0.60)
EDSS
−0.20 (0.05)
0.03 (0.78)
−0.25 (0.01)
0.17 (0.09)
−0.02 (0.85)
-score 25-FTW
0.04 (0.71)
0.16 (0.12)
0.17 (0.10)
0.05 (0.63)
0.03 (0.78)
-score 9-HPT
0.22 (0.03)
−0.23 (0.02)
0.06 (0.55)
−0.27 (0.007)
0.03 (0.75)
-score PASAT-3
0.18 (0.08)
−0.14 (0.17)
0.11 (0.28)
−0.17 (0.10)
0.07 (0.48)
Left Cingulum
Disease duration
−0.27 (0.008)
0.17 (0.09)
−0.14 (0.18)
0.23 (0.02)
−0.09 (0.37)
EDSS
−0.25 (0.01)
0.04 (0.66)
−0.27 (0.006)
0.22 (0.03)
−0.09 (0.40)
-score 25-FTW
0.07 (0.51)
0.09 (0.39)
0.13 (0.21)
−0.02 (0.86)
0.07 (0.47)
-score 9-HPT
0.28 (0.005)
−0.21 (0.03)
0.10 (0.34)
−0.28 (0.005)
0.08 (0.42)
-score PASAT-3
0.31 (0.002)
−0.22 (0.04)
0.06 (0.54)
−0.29 (0.004)
0.15 (0.15)
Right cingulum
Disease duration
−0.13 (0.19)
0.13 (0.19)
−0.07 (0.50)
0.14 (0.17)
−0.07 (0.47)
EDSS
−0.07 (0.49)
0.03 (0.75)
−0.04 (0.72)
0.06 (0.53)
0.04 (0.68)
-score 25FTW
0.05 (0.60)
0.15 (0.15)
0.18 (0.08)
0.06 (0.58)
0.08 (0.46)
-score 9-HPT
0.11 (0.28)
−0.20 (0.05)
−0.07 (0.52)
−0.17 (0.08)
−0.06 (0.54)
-score PASAT-3
0.09 (0.38)
−0.08 (0.40)
0.05 (0.60)
−0.12 (0.22)
−0.005 (0.96)
FA: fractional anisotropy, MD: mean diffusivity, : parallel diffusivity, λ ⊥: perpendicular diffusivity, MTR: magnetization transfer ratio, MSFC: multiple sclerosis functional composite, EDSS: Expanded Disability Status Scale, 25FTW: Timed 25-Foot Walk, 9-HPT: 9-Hole Peg Test, PASAT-3: Paced Auditory serial Addition Task-3, second version. Partial correlation coefficients were adjusted for additive effects of age and sex. Significance levels are shown in parenthesis. Results with are shown in boldface.
