The Contribution of Immune and Glial Cell Types in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Figure 1

Immune and glial cell subtypes and their contributions to the pathogenesis of EAE and MS. During the development and progression of EAE and MS, a variety of cells representing both the innate and adaptive immune system breach the blood brain barrier and invade the brain parenchyma. Resident glial cells also become activated and play an important role in the pathogenesis of EAE and MS. Some of the cell types involved are proinflammatory and promote demyelination, axonal damage, and the formation of disease plaques, whilst other cell types have anti-inflammatory and/or regulatory properties and inhibit disease progression by facilitating tissue repair.