The Prevalence of Familial Multiple Sclerosis in Saskatoon, Saskatchewan

Table 3

Cox proportional analysis: hazard ratios for covariates and interaction terms.

Covariates	Hazard ratio	𝑃 value
MS course
Relapsing-remitting (RR)	1.0
Secondary progressive (SP)	1.5 (95% CI: 0.9–2.4)	0.14
Primary progressive (PP)	3.4 (95% CI: 1.7–6.9)	0.00074
Family history of MS (FHMS)
No	1.0
Yes	0.03 (95% CI: 0.005–0.2)	0.00012
Age of MS onset
<20	1.0
20–29	0.5 (95% CI: 0.2–1.2)	0.11
30–39	0.7 (95% CI: 0.3–1.9)	0.51
≥40	0.9 (95% CI: 0.3–2.6)	0.90
MS course × FHMS (yes)
RR × FHMS	1.0
SP × FHMS	6.6 (95% CI: 1.8–23.7)	0.0037
PP × FHMS	2.5 (95% CI: 0.6–9.5)	0.19
Age of MS onset × FHMS (yes)
Onset <20 × FHMS	1.0
Onset 20–29 × FHMS	5.4 (95% CI: 1.0–29.0)	0.052
Onset 30–39 × FHMS	3.2 (95% CI: 0.5–18.9)	0.20
Onset ≥40 × FHMS	23.2 (95% CI: 3.6–149.5)	0.00093