Treatment with Anti-EGF Ab Ameliorates Experimental Autoimmune Encephalomyelitis via Induction of Neurogenesis and Oligodendrogenesis

Figure 5

Treatment with anti-EGF Ab did not affect inflammatory cell infiltration into the CNS. Estimation of inflammatory infiltrates on day 18 after immunization by hematoxylin and eosin staining. Infiltrates (arrows) were detected in the cortex and striatum of vehicle-treated EAE mice (a and b), in the cortex and fimbria of IC-treated EAE mice (c and d), and in the cortex and fimbria of anti-EGF Ab-treated EAE mice (e and f). Images were obtained by a light microscope. Ctx, cortex, cc, corpus callosum, St, striatum, fi, fimbria, and LV, lateral ventricle. Scale bar: 50 m.