Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials

Table 2

Cross-sectional comparison of retinal layer thickness between Spectralis and Cirrus HD-OCT.

Layer	Average thickness (SD) (μm)	Mean difference (95% CI) (μm)	Upper LOA (95% CI) (μm)	Lower LOA (95% CI) (μm)
mRNFL	32.35 (4.38)	4.71 (4.45 to 4.97)	8.22 (7.77, 8.68)	1.20 (0.74, 1.65)
GCIP	65.59 (8.13)	0.26 (0.04 to 0.48)	3.17 (2.79, 3.55)	−2.65 (−3.03, −2.27)
INL	35.59 (1.81)	−1.31 (−1.43 to −1.12)	0.20 (0.01, 0.40)	−2.83 (−3.03, −2.63)
INL + OPL	60.59 (3.31)	−1.09 (−1.33 to −0.86)	2.02 (1.62, 2.43)	−4.21 (−4.62, −3.81)
ONL	63.10 (5.80)	−2.16 (−2.35, −1.97)	0.39 (0.05, 0.72)	−4.71 (−5.05, −4.38)
ONL + PR	108.56 (7.14)	0.20 (−0.05 to 0.46)	3.61 (3.17, 4.05)	−3.20 (−3.65, −2.76)
RPE	33.32 (1.92)	0.14 (−0.06 to 0.35)	2.92 (2.56, 3.28)	−2.63 (−2.99, −2.27)

Average of thickness values derived from both OCT platforms. mRNFL: macular retinal nerve fiber layer; GCIP: ganglion cell layer + inner plexiform layer; INL: inner nuclear layer; INL + OPL: inner nuclear layer + outer plexiform layer; ONL: outer nuclear layer; ONL + PR: outer nuclear layer + photoreceptor segments; RPE: retinal pigment epithelium.