Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials

Table 3

Longitudinal comparison of retinal layer thicknesses between Spectralis and Cirrus HD-OCT.

Layer	Mean change Spectralis (SD) (μm)	Mean change Cirrus (SD) (μm)	Mean difference (95% CI) (μm)	Upper LOA (95% CI) (μm)	Lower LOA (95% CI) (μm)
mRNFL	−0.29 (2.11)	−0.09 (1.42)	−0.195 (−0.47 to 0.08)	3.52 (3.04, 4.00)	−3.92 (−4.40, −3.43)
GCIP	−0.54 (2.27)	−0.60 (2.16)	0.060 (−0.12 to 0.24)	2.45 (2.15, 2.76)	−2.33 (−2.64, −2.02)
INL	−0.046 (0.69)	−0.004 (0.71)	−0.042 (−0.16 to 0.07)	1.56 (1.36, 1.77)	−1.65 (−1.86, −1.44)
INL + OPL	−0.041 (1.59)	−0.056 (1.17)	0.015 (−0.25 to 0.28)	3.54 (3.09, 4.00)	−3.51 (−3.97, −3.06)
ONL	−0.073 (1.60)	−0.089 (1.33)	0.016 (−0.17 to 0.20)	2.55 (2.22, 2.87)	−2.52 (−2.85, −2.19)
ONL + PR	0.04 (2.20)	−0.17 (1.91)	0.213 (−0.03 to 0.45)	3.42 (3.01, 3.84)	−3.00 (−3.42, −2.59)
RPE	−0.023 (1.01)	−0.032 (1.05)	0.009 (−0.15 to 0.17)	2.21 (1.93, 2.50)	−2.20 (−2.49, −1.91)

mRNFL: macular retinal nerve fiber layer; GCIP: ganglion cell layer + inner plexiform layer; INL: inner nuclear layer; INL + OPL: inner nuclear layer + outer plexiform layer; ONL: outer nuclear layer; ONL + PR: outer nuclear layer + photoreceptor segments; RPE: retinal pigment epithelium.