Applying an Open-Source Segmentation Algorithm to Different OCT Devices in Multiple Sclerosis Patients and Healthy Controls: Implications for Clinical Trials

Table 4

Comparison of the rates of change of retinal layer thickness between Spectralis and Cirrus HD-OCT.

Layer	Rate of change of layer thickness, Spectralis; mean (95% CI) (μm/year)	value	Rate of change of layer thickness, Cirrus; mean (95% CI) (μm/year)	value
mRNFL	−0.28 (−0.56, −0.001)	0.049	−0.09 (−0.28, 0.09)	0.326
GCIP	−0.59 (−0.89, −0.27)	<0.001	−0.66 (−0.96, −0.36)	<0.001
INL	−0.07 (−0.16, 0.01)	0.102	−0.06 (−0.16, 0.03)	0.198
INL + OPL	−0.08 (−0.27, 0.11)	0.419	−0.11 (−0.26, 0.04)	0.157
ONL	−0.06 (−0.25, 0.13)	0.526	−0.11 (−0.27, 0.05)	0.196
ONL + PR	0.05 (−0.21, 0.31)	0.689	−0.16 (−0.39, 0.07)	0.166
RPE	0.004 (−0.12, 0.12)	0.947	−0.002 (−0.13, 0.12)	0.971

mRNFL: macular retinal nerve fiber layer; GCIP: ganglion cell layer + inner plexiform layer; INL: inner nuclear layer; INL + OPL: inner nuclear layer + outer plexiform layer; ONL: outer nuclear layer; ONL + PR: outer nuclear layer + photoreceptor segments; RPE: retinal pigment epithelium.