The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex

Figure 2

Restraint stress upregulated c-Fos in the PrL (a) and IL (b) cortex. Pretreatment with the mGlu2/3 agonist LY354740 (10 mg/kg, i.p.) attenuated the restraint-induced increase in c-Fos expression in both the PrL and IL cortex. * indicates significantly different from vehicle + home cage; ***𝑃<0.001. ^# indicates significantly different from vehicle + restraint stress; ^##𝑃<0.01. One-way ANOVA with Newman-Keuls post hoc test. Each bar represents the mean (±SEM), 𝑛=7-8.

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