Human Cytomegalovirus Latency: Targeting Differences in the Latently Infected Cell with a View to Clearing Latent Infection

Figure 1

HCMV-induced disease pathology. HCMV causes disease in individuals where the immune system is compromised. Mental retardation, deafness, and blindness can occur following in utero primary infection [5–8]. Retinitis occurs following primary infection and reactivation in AIDS patients [23]. Pneumonitis, hepatitis, nephritis, and gastroenteritis/colitis can occur following immune suppression [1, 4, 10, 18, 24, 25]. HCMV has also been suggested to play a role in atherosclerosis and glioma progression [13, 16, 17, 20, 21, 26–28].