Restricting MYC expression and activity. Each stage in MYC expression, from transcription of the MYC gene through to a functionally active MYC protein, are presented in terms of the central dogma. Events that control or suppress these stages are indicated by red boxes. Many of these processes are perturbed in cancer. See text for details. TXN, transcription; TLN, translation; PTMs, post-translational modifications.
