Frequency and location of lymphoma-associated point mutations in c-MYC. The histogram shows the number of times that independent point mutations altering the coding sequence of c-MYC have been reported in the literature, isolated from either patient samples or cultured cell lines. Duplicate identifications (e.g., those occurring in the same cell line but reported by different investigators) have been removed. The analysis did not differentiate between conservative and nonconservative amino acid changes. The histogram is fit to scale atop a cartoon of MYC, showing conserved sequences, functional elements, and regions involved in controlling the metabolic stability of the protein.
