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Journal of Neural Transplantation and Plasticity
Volume 3 (1992), Issue 4, Pages 240-241
doi:10.1155/NP.1992.240
Defining the Range of Cellular Components, Including Internal Antigens, That Can Serve as Targets of Graft Rejection
Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston 02115, MA, USA
Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The mechanisms underlying rejection of grafted neural tissue are still being defined. Mechanisms relevant to genetically engineered cells are of current interest. To date, attention has focused on major histocompatibility complex (MHC) antigens as targets of graft rejection. Yet even when there is no MHC disparity, as when the patient's own cells are genetically altered, there is still a potential for graft rejection, directed against the novel antigens. We illustrate this in a rat model.