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Neural Plasticity
Volume 11 (2004), Issue 3-4, Pages 217-240
http://dx.doi.org/10.1155/NP.2004.217

Genetic Dissection of Learning and Memory in Mice

1Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester 01604, MA, USA
2SGDP Research Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
3Yale School of Medecine, Department of Psychiatry, 34 Park Street, 3rd Floor Research, New Haven 06508, CT, USA

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this minireview, we discuss different strategies to dissect genetically the keystones of learning and memory. First, we broadly sketch the neurogenetic analysis of complex traits in mice. We then discuss two general strategies to find genes affecting learning and memory: candidate gene studies and whole genome searches. Next, we briefly review more recently developed techniques, such as microarrays and RNA interference. In addition, we focus on gene-environment interactions and endophenotypes. All sections are illustrated with examples from the learning and memory field, including a table summarizing the latest information about genes that have been shown to have effects on learning and memory.