Neurobiology of Memory and Anxiety: From Genes to Behavior

Kalueff, Allan V.

doi:https://doi.org/10.1155/2007/78171

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Volume 2007 | Article ID 078171 | https://doi.org/10.1155/2007/78171

Neurobiology of Memory and Anxiety: From Genes to Behavior

Allan V. Kalueff¹

Academic Editor: Georges Chapouthier

Received15 May 2006

Revised15 Nov 2006

Accepted16 Nov 2006

Published09 Jan 2007

Abstract

Interaction of anxiety and memory represents an essential feature of CNS functioning. This paper reviews experimental data coming from neurogenetics, neurochemistry, and behavioral pharmacology (as well as parallel clinical findings) reflecting different mechanisms of memory-anxiety interplay, including brain neurochemistry, circuitry, pharmacology, neuroplasticity, genes, and gene-environment interactions. It emphasizes the complexity and nonlinearity of such interplay, illustrated by a survey of anxiety and learning/memory phenotypes in various genetically modified mouse models that exhibit either synergistic or reciprocal effects of the mutation on anxiety levels and memory performance. The paper also assesses the putative role of different neurotransmitter systems and neuropeptides in the regulation of memory processes and anxiety, and discusses the role of neural plasticity in these mechanisms.

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Copyright © 2007 Allan V. Kalueff. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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