Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus
Figure 4
Object recognition training induces Zif268
and Narp protein expression in the dentate gyrus. Zif268 immunohistochemistry
reveals the presence of Zif268 protein in granule cells in both blades
of the dentate gyrus of (a) CC, (b) C60, and (c) L60 animals. (d) Higher
magnification shows the presence of Zif268 in the nucleus of granule cells.
(e) Change in density of Zif268-positive nuclei (relative to the CC group) in the
dorsal and the ventral blade of the dentate gyrus across the C60 and L60 groups. Narp immunohistochemistry reveals the presence of Narp protein in granule
cells in both blades of the dentate gyrus of (f) CC, (g) C60, and (h) L60 animals. (i) Higher magnification shows the presence of Narp in the cell body of
granule cells. (j) Change in density of Narp-positive cells (relative to the CC
group) in the dorsal and the ventral blade of the dentate gyrus across the C60
and L60 groups. Data are presented as mean ± SEM ( for all groups).
Asterisks indicate (if not indicated otherwise, relative to CC
group). Scale bars represent 200 m in (a)–(c) and (f)-(h) and 50 m in
(d) and (i).
