Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization
Figure 2
Time-course of LTP induced in the medial
entorhinal cortex of 55–60-day-old normal
eutrophic rats by applying tetanizing stimulation to the occipital cortex (a) or
to the ventral CA1 hippocampal region (b). The arrow indicates time of
application of the tetanizing stimulus. rats in all groups. Values are
means ± SEM of peak-to-peak amplitudes, 30 responses averaged per rat. Note the
occurrence of homosynaptic, but not heterosynaptic potentiation. One-way ANOVA followed
by Dunnett’s multiple comparisons test indicated significant intragroup differences
in peak-to-peak amplitudes (, ) when comparing
post-tetanizing values with the last pretetanizing basal point (at 0 minute),
excepting for block 2.5–5 minutes (a),
where significant inhibition () occurred.
