Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization
Figure 3
Failure of tetanizing stimulation applied to
the occipital cortex (a) or to the ventral CA1 hippocampal region (b) to induce
LTP in the medial entorhinal cortex of 55–60-day-old prenatally
malnourished rats. The arrow indicates time of application of the tetanizing
stimulus. rats in all groups. Values are means ± SEM of peak-to-peak
amplitudes, 30 responses averaged per rat. It can be noted that neither
homosynaptic nor heterosynaptic potentiation occurred in the EC of malnourished
animals. One-way ANOVA followed by Dunnett’s multiple comparisons test
indicated no significant intragroup differences in peak-to-peak amplitudes when
comparing posttetanizing values with the last pretetanizing basal point (at 0
minute), excepting for block 2.5–5 minutes (a) where
significant inhibition () occurred.
