Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex
Figure 10
Expression of LTP in the
ascending pathway was associated with a slight change in PPF ratio. (a) Normalized scaled amplitude of the peak
EPSCs evoked by the first of a pair of test pulses separated by 60 milliseconds
(filled circles), and the normalized PPF ratio (open circles) in a layer II
cell is plotted against time. The inset shows two traces reflecting averaged
paired EPSCs at baseline (pre-HFS) and at 30 minutes post-HFS. PPF ratio was
calculated as the amplitude of the peak of the second EPSC divided by the
first. (b) Average normalized scaled
amplitude of PPF ratio in 8 cells. HFS at time zero induced a short-term
decrease of PPF which decayed back to near baseline levels. The values at 30
and 50 minutes after HFS, however, ( and , resp.)
were significantly different from baseline ().
