Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex
Figure 13
Induction of LTP in the ascending
pathway was partially dependent upon intact PKA signalling. (a) Normalized scaled amplitude of peak
EPSCs evoked by test pulses in a layer II cell is plotted against time. Time
point of application of 250 nM KT5720 is indicated by the line. HFS led to intact
short-term potentiation (PTP) but the degree of long-term potentiation was
slightly decreased although still intact. The inset shows two traces reflecting
averaged EPSCs at baseline (pre-HFS) and at 30 minutes post-HFS. (b) Average normalized scaled amplitude
of peak EPSCs across 10 cells in the presence of KT5720 as indicated by the
line. The value 30 minutes after HFS was which was significantly
different from baseline values () but was also significantly
reduced in comparison to control conditions ().
