Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex
Figure 5
Induction of LTP in the horizontal
pathway required an increase in postsynaptic calcium. (a) Normalized scaled amplitude of peak EPSCs evoked by test pulses
in a layer II cell loaded with 10 mM BAPTA is plotted against time. HFS was
routinely applied about 15 minutes after formation of whole-cell mode to ensure
adequate BAPTA diffusion. The inset shows two traces reflecting averaged EPSCs
at baseline (pre-HFS) and at 30 minutes post-HFS. (b) Average normalized scaled amplitude of peak EPSCs across 5
BAPTA-loaded cells. HFS at time zero induced only short-term (PTP) but not
long-term potentiation. The value at 30
minutes post-HFS () was not significantly different
from baseline ().
