Differential Induction of Long-Term Potentiation in the Horizontal versus Columnar Superficial Connections to Layer II Cells of the Entorhinal Cortex
Figure 9
Induction of LTP in the ascending
pathway was not blocked by sequestering of free postsynaptic calcium. (a) Normalized scaled amplitude of peak
EPSCs evoked by test pulses in a layer II cell loaded with 10 mM BAPTA is
plotted against time. HFS was routinely applied about 15 minutes after
formation of whole-cell mode to ensure adequate BAPTA diffusion. The inset
shows two traces reflecting averaged EPSCs at baseline (pre-HFS) and at 30
minutes post-HFS. HFS-induced enhancement of EPSCs was still observed. (b) Average normalized scaled amplitude
of peak EPSCs across 5 BAPTA-loaded cells. HFS at time zero induced both
short-term (PTP) and long-term potentiation. The value at 30 minutes post-HFS () was slightly reduced compared
to control conditions but significantly different from baseline ().
