The Role of NMDA Receptor Subtypes in Short-Term Plasticity in the Rat Entorhinal Cortex
Figure 5
Effect of subunit selective
antagonists on postsynaptic NMDAr-mediated eEPSCs. Slow eEPSCs were recorded at
+40 mV in the presence of NBQX and bicuculline. Each response is the average of
at least 8 events. (a) The NR2B antagonist, Ro 25-691, induced a
concentration-dependent reduction in slow eEPSCs. They were essentially
abolished at the higher concentration. (b) and (c) show that NR2A selective
blockers induced a very similar blockade of slow EPSCs. (d) A combination of
NR2A and NR2B antagonists also abolished slow EPSCs.
