5-Lipoxygenase DNA Methylation and mRNA Content in the Brain and Heart of Young and Old Mice
Figure 5
DNMT1 (a) and DNMT3a (b) mRNA levels in heart and brain tissues of young and old mice. The content of DNMT1/DNMT3a mRNA in the tissues of young and old mice was measured by real-time PCR. The results were normalized against the corresponding cyclophilin mRNA contents and are presented as units (the coefficient of variation values amplified by a factor of 1000, see text for details). Data are expressed as mean ± S.E.M (). Note that the only aging-associated difference was observed for DNMT3a mRNA content in the heart (#, -test). The content of DNMT mRNA was generally greater in the heart compared to the brain; * and * versus the corresponding values in the heart in the same age group (Dunnett's test).
