Synaptic Remodeling in the Dentate Gyrus, CA3, CA1, Subiculum, and Entorhinal Cortex of Mice: Effects of Deprived Rearing and Voluntary Running

Table 1

Absolute numbers of silver-stained precipitates in equally sized measuring fields in different hippocampal regions and laminae.

			Number of precipitates
Measuring field			ER	DR			ER after wheel running			DR after wheel running
			Value (abs)	Value (abs)	difference ER $-$ DR (%)	$P$	value (abs)	difference ER $-$ ER after wheel running (%)	$P$	Value (abs)	difference DR $-$ DR after wheel running (%)	$P$
dentate gyrus	oML	spb	224	242	8	n.s.	195	$-$13	n.s.	181	$-$25	n.s.
		ipb	217	216	$-$1	n.s.	167	$-$23	n.s.	194	$-$10	n.s.
	mML	spb	224	240	7	n.s.	182	$-$19	n.s.	182	$-$24	n.s.
		ipb	233	240	3	n.s.	168	$-$28	n.s.	184	$-$23	n.s.
	iML	spb	270	291	8	n.s.	205	$-$24	n.s.	228	$-$21	n.s.
		ipb	258	275	7	n.s.	190	$-$26	n.s.	209	$-$24	n.s.
	gcl	spb	92	106	16	n.s.	70	$-$23	n.s.	125	18	n.s.
		ipb	109	131	20	n.s.	76	$-$31	n.s.	129	$-$2	n.s.
	sgl	spb	292	334	14	n.s.	228	$-$22	n.s.	265	$-$21	n.s.
		ipb	344	381	11	n.s.	250	$-$27	n.s.	284	$-$25	n.s.
CA3	So		230	265	15	n.s.	164	$-$29	n.s.	171	$-$35	n.s.
	Sp		91	105	16	n.s.	127	40	n.s.	224	113	.09
	Sl		267	292	9	n.s.	159	$-$41	.09	208	$-$29	n.s.
	Sr		333	368	11	n.s.	221	$-$34	.07	253	$-$31	n.s.
CA1	So		273	284	4	n.s.	184	$-$33	n.s.	169	$-$40	.06
	Sp		57	89	56	n.s.	62	8	n.s.	94	6	n.s.
	Sr		294	302	3	n.s.	179	$-$39	<.05	195	$-$36	n.s.
	Slm		335	378	13	n.s.	250	$-$25	n.s.	249	$-$34	<.05
EC	L II		213	170	$-$20	n.s.	201	$-$6	n.s.	202	19	n.s.
	L III		269	219	$-$18	n.s.	195	$-$28	n.s.	196	$-$11	n.s.
Subiculum			250	267	7	n.s.	224	$-$11	n.s.	237	$-$11	n.s.

ER: reared under socially and physically enriched conditions (pd 21–74); DR: reared under socially and physically deprived conditions; after wheel running: after an additional wheel running challenge in adulthood (pd 74–78); oML: outer molecular layer; mML: intermediate molecular layer; iML: inner molecular layer; gcl: granule cell layer; sgl: subgranular layer; spb: suprapyramidal blade; ipb: infrapyramidal blade; So: stratum oriens, Sp: stratum pyramidale; Sl: stratum lucidum; Sr: stratum radiatum; Slm: stratum lacunosum-moleculare; EC: entorhinal cortex; L: lamina; statistical differences between laminae only shown in Figure 3.