Structural organization of GABAergic synapses. The postsynaptic organization comprises a large number of proteins that allow the correct targeting, clustering and stabilization of GABA_A receptors. Among them gephyrin forms hexagonal lattices that trap GABA_A receptors in precise apposition to presynaptic release sites. Cell adhesion molecules of the neuroligin-neurexin families bridge the cleft and ensure transsynaptic signaling, essential for the maintenance of a proper E/I balance.