Alterations of GABAergic Signaling in Autism Spectrum Disorders

Figure 1

Patterns of electrical activity observed at late embryonic/early postnatal stages in the cortex. E20: uncorrelated calcium spikes; P0: Spontaneous Plateau Assemblies (SPAs) synchronized by gap junctions. P3–P5: early network oscillations (ENOs) mediated by glutamate. P6–P8: giant depolarizing potentials (GDPs) mediated by GABA and glutamate. (Modified from [32]).