|
| Species | Behavioral task | Histaminergic modulator | Lesion or pharmacological induced memory impairment | Effect on memory | Reference(s) |
|
| Rat | Passive avoidance | Histamine | | ↑ | [120, 121] |
| Rat | Passive avoidance | Histamine | | ↓ | [122–124] |
| Mouse | Passive avoidance | Histamine | Lithium (i.p.) | ↑ | [125] |
| Rat | Active avoidance | Histamine | | ↑ | [126] |
| Rat | Active avoidance | Histamine | | ↓ | [127] |
| Rat | Active avoidance | Histamine | Bilateral hippocampectomy (dorsal hippocampus) | ↑ | [128] |
| Rat | Active avoidance | Histamine | alpha-FMH (i.p.) | ↑ | [126] |
| Rat | Habituation in open field | Histamine | | ↑ | [121] |
| Rat | Social memory | Histamine | | ↑ | [129] |
| Rat | Social memory | Histidine | | ↑ | [129] |
| Rat | Social memory | alpha-FMH | | ↓ | [129] |
| Rat | Radial maze | Histamine | N-methyl- d-aspartate (NMDA) receptor glycine site antagonist (7-chlorokynurenic acid) i.c.v | ↑ | [130] |
| Rat | Radial maze | alpha-FMH | | ↓ | [131] |
| Rat | Passive avoidance | H1 receptor antagonist (chlorpheniramine) | | ↑ | [122] |
| Rat | Passive avoidance | H1 receptor antagonist (pyrilamine ) | | ↑ | [124] |
| Rat | Passive avoidance | H2 receptor antagonist (cimetidine) | | ↑ | [123, 124] |
| Mouse | Passive avoidance | H2 receptor agonist (4-methylhistamine) | | ↓ | [90] |
| Rat | Active avoidance | H1 receptor agonist (2-methylhistamine and 2-thiazolylethylamine) | | ↓ | [127] |
| Rat | Step-through active avoidance | H1 receptor agonist (2-methylhistamine) | | ↑ | [132] |
| Rat | Step-through active avoidance | H1 receptor antagonist (pyrilamine or diphenhydramine) | | ↓ | [132] |
| Rat | Social memory | H3 receptor agonist (immepip) | | ↓ | [129] |
| Rat | Social memory | H3 receptor antagonist (thioperamide) | | ↑ | [129] |
| Rat | Object recognition | H1 receptor agonist [2-(3-(trifluoromethyl)-phenyl)histamine] | | ↑ | [133] |
| Rat | Water maze | H1 receptor antagonist (chlorpheniramine) | | ↑ | [134] |
|