Table 3: Intracerebroventricular administration of drugs that act on the histaminergic system and memory performance.

SpeciesBehavioral taskHistaminergic modulatorLesion or pharmacological induced memory impairmentEffect on memoryReference(s)

RatPassive avoidanceHistamine [120, 121]
RatPassive avoidanceHistamine [122124]
MousePassive avoidanceHistamineLithium (i.p.)[125]
RatActive avoidanceHistamine[126]
RatActive avoidanceHistamine[127]
RatActive avoidanceHistamineBilateral hippocampectomy (dorsal hippocampus)[128]
RatActive avoidanceHistaminealpha-FMH (i.p.)[126]
RatHabituation in open fieldHistamine[121]
RatSocial memoryHistamine[129]
RatSocial memoryHistidine[129]
RatSocial memoryalpha-FMH[129]
RatRadial mazeHistamineN-methyl- d-aspartate (NMDA) receptor glycine site antagonist (7-chlorokynurenic acid) i.c.v[130]
RatRadial mazealpha-FMH [131]
RatPassive avoidanceH1 receptor antagonist (chlorpheniramine)[122]
RatPassive avoidanceH1 receptor antagonist (pyrilamine )[124]
RatPassive avoidanceH2 receptor antagonist (cimetidine) [123, 124]
MousePassive avoidanceH2 receptor agonist (4-methylhistamine) [90]
RatActive avoidanceH1 receptor agonist (2-methylhistamine and 2-thiazolylethylamine)[127]
RatStep-through active avoidanceH1 receptor agonist (2-methylhistamine)[132]
RatStep-through active avoidanceH1 receptor antagonist (pyrilamine or diphenhydramine)[132]
RatSocial memoryH3 receptor agonist (immepip)[129]
RatSocial memoryH3 receptor antagonist (thioperamide)[129]
RatObject recognitionH1 receptor agonist [2-(3-(trifluoromethyl)-phenyl)histamine][133]
RatWater mazeH1 receptor antagonist (chlorpheniramine) [134]

alpha-FMH: alpha-fluoromethylhistidine (inhibitor of histamine decarboxylase)
i.p. intraperitoneal
i.c.v intracerebroventricular.